Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor

Mechanisms Underlying Dopaminergic Regulation of Nicotine-Induced Kinetic Tremor

Nicotine induces kinetic tremor, which resembles pharmacological features of essential tremors, via activating the inferior olive (IO) neurons. Since nicotine is known to enhance dopamine release by stimulating α4β2 and/or α6 nACh receptors, we examined the effects of various dopamine receptor ligan...

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Bibliographic Details
Main Authors: Masaki Kato, Naofumi Kunisawa, Saki Shimizu, Higor A. Iha, Yukihiro Ohno
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
nicotine
tremor
dopamine receptors
D3 receptors
inferior olive
cerebellum
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.938175/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.938175/full

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