Linear and conformational determinants of visceral leishmaniasis diagnostic antigens rK28 and rK39

Linear and conformational determinants of visceral leishmaniasis diagnostic antigens rK28 and rK39

Abstract Background Recombinant antigens rK39 (based on kinesin sequence) and rK28 (comprising kinesin and HASPB sequences) are a mainstay of serological diagnosis for visceral leishmaniasis (VL). However, their key epitopes and the significance of their structural conformation are not clearly defin...

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Bibliographic Details
Main Authors: Poppy Simonson, Tapan Bhattacharyya, Sayda El-Safi, Michael A. Miles
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Parasites & Vectors
Subjects:
Visceral leishmaniasis
Serology
Antigens
rK39/rK28
Conformation
Linear epitopes
Online Access:https://doi.org/10.1186/s13071-022-05495-1

Internet

https://doi.org/10.1186/s13071-022-05495-1

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