Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization

Novel 8-Methoxycoumarin-3-Carboxamides with potent anticancer activity against liver cancer via targeting caspase-3/7 and β-tubulin polymerization

Abstract In the present study, we explored the potential of coumarin-based compounds, known for their potent anticancer properties, by designing and synthesizing a novel category of 8-methoxycoumarin-3-carboxamides. Our aim was to investigate their antiproliferative activity against liver cancer cel...

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Bibliographic Details
Main Authors: Ahmad Alzamami, Eman M. Radwan, Eman Abo-Elabass, Mohammed El Behery, Hussah Abdullah Alshwyeh, Ebtesam Al-Olayan, Abdulmalik S. Altamimi, Nashwah G. M. Attallah, Najla Altwaijry, Mariusz Jaremko, Essa M. Saied
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Chemistry
Subjects:
Liver cancer
Coumarin analogues
Antiproliferative activity
Cell cycle arrest
Apoptosis
Flow cytometric analysis
Online Access:https://doi.org/10.1186/s13065-023-01063-5

Internet

https://doi.org/10.1186/s13065-023-01063-5

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