An adapted consensus protein design strategy for identifying globally optimal biotherapeutics

An adapted consensus protein design strategy for identifying globally optimal biotherapeutics

Biotherapeutic optimization, whether to improve general properties or to engineer specific attributes, is a time-consuming process with uncertain outcomes. Conversely, Consensus Protein Design has been shown to be a viable approach to enhance protein stability while retaining function. In adapting t...

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Bibliographic Details
Main Authors: Yanyun Liu, Kenny Tsang, Michelle Mays, Gale Hansen, Jeffrey Chiecko, Maureen Crames, Yangjie Wei, Weijie Zhou, Chase Fredrick, James Hu, Dongmei Liu, Douglas Gebhard, Zhong-Fu Huang, Akshita Datar, Anthony Kronkaitis, Kristina Gueneva-Boucheva, Daniel Seeliger, Fei Han, Saurabh Sen, Srinath Kasturirangan, Justin M. Scheer, Andrew E. Nixon, Tadas Panavas, Michael S. Marlow, Sandeep Kumar
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
Consensus protein design
biotherapeutics
bioinformatics
molecular modeling
developability
data science
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2073632

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2073632

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