A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats

A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats

Mammary tumors are the most prevalent type of tumors in female dogs. Breast cancer 2, early onset (<i>BRCA2</i>) malignant mutations are associated with tumorigenesis in humans and dogs. BRCA2 plays a pivotal role in homologous recombination repair by recruiting RAD51 recombinase to DNA...

Full description

Bibliographic Details
Main Authors: Zida Zhu, Taisuke Kitano, Masami Morimatsu, Kazuhiko Ochiai, Toshina Ishiguro-Oonuma, Kosuke Oosumi, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Veterinary Sciences
Subjects:
BRCA2
RAD51
BRC repeats
highly conserved region
comparative molecular biology
mutation analysis
Online Access:https://www.mdpi.com/2306-7381/10/2/145

Internet

https://www.mdpi.com/2306-7381/10/2/145

Similar Items