Exploring the Role of RGD-Recognizing Integrins in Cancer

Exploring the Role of RGD-Recognizing Integrins in Cancer

Integrins are key regulators of communication between cells and with their microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif Arg-Gly-Asp (RGD) within extracelluar matrix (ECM) proteins. These integrins constitute an important subfamily and play a major role i...

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Bibliographic Details
Main Authors: Markus Nieberler, Ute Reuning, Florian Reichart, Johannes Notni, Hans-Jürgen Wester, Markus Schwaiger, Michael Weinmüller, Andreas Räder, Katja Steiger, Horst Kessler
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Cancers
Subjects:
RGD-recognizing integrins
αvβ3
αvβ5
αvβ6
αvβ8
α5β1
α8β1
integrin adhesion
migration
apoptosis
and signaling
synthetic integrin ligands
cyclic peptide
peptidomimetics
Cilengitide
epithelial-mesenchymal transition (EMT)
transforming growth factor-β (TGF-β)
metastasis
angiogenesis
Online Access:https://www.mdpi.com/2072-6694/9/9/116

Internet

https://www.mdpi.com/2072-6694/9/9/116

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