Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells.

Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells.

Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum (ER) to the Golgi complex. Its deficiency in mouse leads to embryonic death at E11.5. CERT deficient embryos die from cardiac failure due to defective organogenesis, but not due to ceramide induced apoptotic or necrot...

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Bibliographic Details
Main Authors: Raghavendra Pralhada Rao, Luana Scheffer, Sargur M Srideshikan, Velayoudame Parthibane, Teresa Kosakowska-Cholody, M Athar Masood, Kunio Nagashima, Prabhakar Gudla, Stephen Lockett, Usha Acharya, Jairaj K Acharya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958450?pdf=render

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http://europepmc.org/articles/PMC3958450?pdf=render

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