<i>POLD1</i> DEDD Motif Mutation Confers Hypermutation in Endometrial Cancer and Durable Response to Pembrolizumab

<i>POLD1</i> DEDD Motif Mutation Confers Hypermutation in Endometrial Cancer and Durable Response to Pembrolizumab

Background: Mutations in the DNA polymerase delta 1 (POLD1) exonuclease domain cause DNA proofreading defects, hypermutation, hereditary colorectal and endometrial cancer, and are predictive of immunotherapy response. Exonuclease activity is carried out by two magnesium cations, bound to four highly...

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Bibliographic Details
Main Authors: Christina Hsiao Wei, Edward Wenge Wang, Lingzi Ma, Yajing Zhou, Li Zheng, Heather Hampel, Susan Shehayeb, Stephen Lee, Joshua Cohen, Adrian Kohut, Fang Fan, Steven Rosen, Xiwei Wu, Binghui Shen, Yuqi Zhao
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cancers
Subjects:
DNA polymerase delta
POLD1
endometrial cancer
hypermutation
germline
variant of uncertain significance
Online Access:https://www.mdpi.com/2072-6694/15/23/5674

Internet

https://www.mdpi.com/2072-6694/15/23/5674

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