Molecular determinants of complexin clamping and activation function

Molecular determinants of complexin clamping and activation function

Previously we reported that Synaptotagmin-1 and Complexin synergistically clamp the SNARE assembly process to generate and maintain a pool of docked vesicles that fuse rapidly and synchronously upon Ca2+ influx (Ramakrishnan et al., 2020). Here, using the same in vitro single-vesicle fusion assay, w...

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Bibliographic Details
Main Authors: Manindra Bera, Sathish Ramakrishnan, Jeff Coleman, Shyam S Krishnakumar, James E Rothman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
synaptic vesicle
membrane fusion
calcium regulation
complexin
synaptotagmin
Online Access:https://elifesciences.org/articles/71938

Internet

https://elifesciences.org/articles/71938

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