Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis

Regulation of Decay Accelerating Factor Primes Human Germinal Center B Cells for Phagocytosis

Germinal centers (GC) are sites for extensive B cell proliferation and homeostasis is maintained by programmed cell death. The complement regulatory protein Decay Accelerating Factor (DAF) blocks complement deposition on host cells and therefore also phagocytosis of cells. Here, we show that B cells...

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Bibliographic Details
Main Authors: Andy Dernstedt, Jana Leidig, Anna Holm, Priscilla F. Kerkman, Jenny Mjösberg, Clas Ahlm, Johan Henriksson, Magnus Hultdin, Mattias N. E. Forsell
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
human B cell development
germinal center (GC)
decay accelerating factor (DAF)
complement-mediated phagocytosis
complement regulating proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.599647/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.599647/full

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