Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage
Summary: White adipose tissue (WAT) development and adult homeostasis rely on distinct adipocyte progenitor cells (APCs). While adult APCs are defined early during embryogenesis and generate adipocytes after WAT organogenesis, the mechanisms underlying adult adipose lineage determination and preserv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223027591 |
| _version_ | 1827395910261276672 |
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| author | Abigail M. Benvie Derek Lee Yuwei Jiang Daniel C. Berry |
| author_facet | Abigail M. Benvie Derek Lee Yuwei Jiang Daniel C. Berry |
| author_sort | Abigail M. Benvie |
| collection | DOAJ |
| description | Summary: White adipose tissue (WAT) development and adult homeostasis rely on distinct adipocyte progenitor cells (APCs). While adult APCs are defined early during embryogenesis and generate adipocytes after WAT organogenesis, the mechanisms underlying adult adipose lineage determination and preservation remain undefined. Here, we uncover a critical role for platelet-derived growth factor receptor beta (Pdgfrβ) in identifying the adult APC lineage. Without Pdgfrβ, APCs lose their adipogenic competency to incite fibrotic tissue replacement and inflammation. Through lineage tracing analysis, we reveal that the adult APC lineage is lost and develops into macrophages when Pdgfrβ is deleted embryonically. Moreover, to maintain the APC lineage, Pdgfrβ activation stimulates p38/MAPK phosphorylation to promote APC proliferation and maintains the APC state by phosphorylating peroxisome proliferator activated receptor gamma (Pparγ) at serine 112. Together, our findings identify a role for Pdgfrβ acting as a rheostat for adult adipose lineage confinement to prevent unintended lineage switches. |
| first_indexed | 2024-03-08T18:42:46Z |
| format | Article |
| id | doaj.art-4c9f76ae2a1f4fc7963194098d830722 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T18:42:46Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-4c9f76ae2a1f4fc7963194098d8307222023-12-29T04:45:55ZengElsevieriScience2589-00422024-01-01271108682Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineageAbigail M. Benvie0Derek Lee1Yuwei Jiang2Daniel C. Berry3Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USADepartment of Physiology and Biophysics, University of Illinois College of Medicine at Chicago, Chicago, IL 60612, USADivision of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA; Corresponding authorSummary: White adipose tissue (WAT) development and adult homeostasis rely on distinct adipocyte progenitor cells (APCs). While adult APCs are defined early during embryogenesis and generate adipocytes after WAT organogenesis, the mechanisms underlying adult adipose lineage determination and preservation remain undefined. Here, we uncover a critical role for platelet-derived growth factor receptor beta (Pdgfrβ) in identifying the adult APC lineage. Without Pdgfrβ, APCs lose their adipogenic competency to incite fibrotic tissue replacement and inflammation. Through lineage tracing analysis, we reveal that the adult APC lineage is lost and develops into macrophages when Pdgfrβ is deleted embryonically. Moreover, to maintain the APC lineage, Pdgfrβ activation stimulates p38/MAPK phosphorylation to promote APC proliferation and maintains the APC state by phosphorylating peroxisome proliferator activated receptor gamma (Pparγ) at serine 112. Together, our findings identify a role for Pdgfrβ acting as a rheostat for adult adipose lineage confinement to prevent unintended lineage switches.http://www.sciencedirect.com/science/article/pii/S2589004223027591Molecular biologyCell biologyEmbryology |
| spellingShingle | Abigail M. Benvie Derek Lee Yuwei Jiang Daniel C. Berry Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage iScience Molecular biology Cell biology Embryology |
| title | Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| title_full | Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| title_fullStr | Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| title_full_unstemmed | Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| title_short | Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| title_sort | platelet derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage |
| topic | Molecular biology Cell biology Embryology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223027591 |
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