Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model.

Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model.

Glaucomatous axon injury occurs at the level of the optic nerve head (ONH) in response to uncontrolled intraocular pressure (IOP). The temporal response of ONH astrocytes (glial cells responsible for axonal support) to elevated IOP remains unknown. Here, we evaluate the response of actin-based astro...

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Bibliographic Details
Main Authors: Shandiz Tehrani, Lauren Davis, William O Cepurna, Tiffany E Choe, Diana C Lozano, Ashley Monfared, Lauren Cooper, Joshua Cheng, Elaine C Johnson, John C Morrison
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5125687?pdf=render

Internet

http://europepmc.org/articles/PMC5125687?pdf=render

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