Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis

Mutations in JAK2 and Calreticulin genes are associated with specific alterations of the immune system in myelofibrosis

Myelofibrosis (MF) is a clonal neoplasia associated with chronic inflammation due to aberrant cytokine production. Mutations in Janus Kinase-2 (JAK2), calreticulin (CALR) and myeloproliferative leukemia protein (MPL) genes have been recently associated to MF and they all activate the JAK/STAT signal...

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Bibliographic Details
Main Authors: Marco Romano, Daria Sollazzo, Sara Trabanelli, Martina Barone, Nicola Polverelli, Margherita Perricone, Dorian Forte, Simona Luatti, Michele Cavo, Nicola Vianelli, Camilla Jandus, Francesca Palandri, Lucia Catani
Format: Article
Language:English
Published: Taylor & Francis Group 2017-10-01
Series:OncoImmunology
Subjects:
calreticulin
chronic inflammation
immune dysregulation
jak2(v617f)
myelofibrosis
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1345402

Internet

http://dx.doi.org/10.1080/2162402X.2017.1345402

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