Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay

Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay

Introduction: Adherence to medication is an important determinant of outcomes in chronic diseases like heart failure. Drug assays provide objective adherence biomarkers. Dried blood spots (DBS) are appealing samples for drug assays due to less demanding transportation and storage requirements. Objec...

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Bibliographic Details
Main Authors: Andre Joubert, Anton Joubert, Marthinus van der Merwe, Jennifer Norman, Sandra Castel, Paolo Denti, Karen Sliwa, Gary Maartens, Phumla Sinxadi, Lubbe Wiesner
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Mass Spectrometry and Advances in the Clinical Lab
Subjects:
Carvedilol
Enalaprilat
Perindoprilat
LC-MS/MS
Dried blood spots
Adherence
Online Access:http://www.sciencedirect.com/science/article/pii/S2667145X22000451

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http://www.sciencedirect.com/science/article/pii/S2667145X22000451

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