Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer

Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer

Abstract Natural killer (NK) cells play essential roles in the tumor development, diagnosis, and prognosis of tumors. In this study, we aimed to establish a reliable signature based on marker genes in NK cells, thus providing a new perspective for assessing immunotherapy and the prognosis of patient...

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Bibliographic Details
Main Authors: Jian-Rong Sun, Chen-Fan Kong, Yi-Xiang Ye, Qin Wang, Xiang-Ke Qu, Li-Qun Jia, Song Wu
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Single-cell RNA-sequencing
Bulk RNA sequencing
NK cell
Prognostic signature
Tumor microenvironment
Immunotherapy response
Online Access:https://doi.org/10.1038/s41598-024-57714-7

Internet

https://doi.org/10.1038/s41598-024-57714-7

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