Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-β1: a structure–function analysis

Exploring alveolar recruitability using positive end-expiratory pressure in mice overexpressing TGF-β1: a structure–function analysis

Abstract Pre-injured lungs are prone to injury progression in response to mechanical ventilation. Heterogeneous ventilation due to (micro)atelectases imparts injurious strains on open alveoli (known as volutrauma). Hence, recruitment of (micro)atelectases by positive end-expiratory pressure (PEEP) i...

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Bibliographic Details
Main Authors: Franziska Roeder, Tina Röpke, Lara-Kristin Steinmetz, Martin Kolb, Ulrich A. Maus, Bradford J. Smith, Lars Knudsen
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Acute respiratory distress syndrome
Ventilation induced lung injury
TGF-β1
Recruitment
Atelectasis
Stereology
Online Access:https://doi.org/10.1038/s41598-024-58213-5

Internet

https://doi.org/10.1038/s41598-024-58213-5

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