Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9

Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9

Here, we characterized the first French NDM-9-producing Acinetobacter baumannii isolate. A. baumannii 13A297, which belonged to the STPas25 (international clone IC7), was highly resistant to β-lactams including cefiderocol (MIC >32 mg/L). Whole genome sequencing (WGS) using both Illumina and...

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Bibliographic Details
Main Authors: Susie Gaillot, Saoussen Oueslati, Jean-Baptiste Vuillemenot, Maxime Bour, Bogdan I. Iorga, Pauline Triponney, Patrick Plésiat, Rémy A. Bonnin, Thierry Naas, Katy Jeannot, Anaïs Potron
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Microbiology
Subjects:
Acinetobacter baumannii
cefiderocol
carbapenemases
NDM
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1253160/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1253160/full

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