Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines

Deciphering the Mechanisms of Improved Immunogenicity of Hypochlorous Acid-Treated Antigens in Anti-Cancer Dendritic Cell-Based Vaccines

Hypochlorous acid (HOCl)-treated whole tumor cell lysates (Ox-L) have been shown to be more immunogenic when used as an antigen source for therapeutic dendritic cell (DC)-based vaccines, improving downstream immune responses both in vitro and in vivo. However, the mechanisms behind the improved immu...

Full description

Bibliographic Details
Main Authors: Michele Graciotti, Fabio Marino, HuiSong Pak, Petra Baumgaertner, Anne-Christine Thierry, Johanna Chiffelle, Marta A. S. Perez, Vincent Zoete, Alexandre Harari, Michal Bassani-Sternberg, Lana E. Kandalaft
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Vaccines
Subjects:
dendritic cells
cancer vaccines
immunotherapy
proteomics
immunopeptidomics
Online Access:https://www.mdpi.com/2076-393X/8/2/271

Internet

https://www.mdpi.com/2076-393X/8/2/271

Similar Items