A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines

A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines

Cancer and parasitic diseases, such as leishmaniasis and Chagas disease, share similarities that allow the co-development of new antiproliferative agents as a strategy to quickly track the discovery of new drugs. This strategy is especially interesting regarding tropical neglected diseases, for whic...

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Bibliographic Details
Main Authors: Paulo Pitasse-Santos, Eduardo Salustiano, Raynná Bittencourt Pena, Otávio Augusto Chaves, Leonardo Marques da Fonseca, Kelli Monteiro da Costa, Carlos Antônio do Nascimento Santos, Jhenifer Santos Dos Reis, Marcos André Rodrigues da Costa Santos, Jose Osvaldo Previato, Lucia Mendonça Previato, Leonardo Freire-de-Lima, Nelilma Correia Romeiro, Lúcia Helena Pinto-da-Silva, Célio G. Freire-de-Lima, Débora Decotè-Ricardo, Marco Edilson Freire-de-Lima
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Tropical Medicine and Infectious Disease
Subjects:
chagas disease
<i>Trypanosoma cruzi</i>
<i>Leishmania amazonensis</i>
anticancer
chronic myeloid leukemia
molecular docking
Online Access:https://www.mdpi.com/2414-6366/7/12/403

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https://www.mdpi.com/2414-6366/7/12/403

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