Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting

Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting

Abstract Background Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a CLAM-LC-MS/MS system, which consists of a sample pr...

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Bibliographic Details
Main Authors: Tsutomu Shimada, Daisuke Kawakami, Arimi Fujita, Rintaro Yamamoto, Satoshi Hara, Kiyoaki Ito, Ichiro Mizushima, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Mitsuhiro Kawano, Takashi Wada, Yoshimichi Sai
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
CLAM-LC-MS/MS
Automatic pretreatment
Immunoassay
Tacrolimus
Cyclosporin A
Online Access:https://doi.org/10.1186/s40780-023-00318-6

Internet

https://doi.org/10.1186/s40780-023-00318-6

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