Genome-wide association testing in malaria studies in the presence of overdominance
Abstract Background In human genetics, heterozygote advantage (heterosis) has been detected in studies that focused on specific genes but not in genome-wide association studies (GWAS). For example, heterosis is believed to confer resistance to certain strains of malaria in patients heterozygous for...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-04-01
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Series: | Malaria Journal |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-023-04533-2 |