LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3
The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. Using huma...
| Asıl Yazarlar: | , , , , , , , , , |
|---|---|
| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
American Society for Clinical investigation
2023-07-01
|
| Seri Bilgileri: | JCI Insight |
| Konular: | |
| Online Erişim: | https://doi.org/10.1172/jci.insight.167310 |