LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

LIN28B promotes cell invasion and colorectal cancer metastasis via CLDN1 and NOTCH3

The RNA-binding protein LIN28B is overexpressed in over 30% of patients with colorectal cancer (CRC) and is associated with poor prognosis. In the present study, we unraveled a potentially novel mechanism by which LIN28B regulates colonic epithelial cell-cell junctions and CRC metastasis. Using huma...

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Bibliographic Details
Main Authors: Kensuke Sugiura, Yasunori Masuike, Kensuke Suzuki, Alice E. Shin, Nozomu Sakai, Hisahiro Matsubara, Masayuki Otsuka, Peter A. Sims, Christopher J. Lengner, Anil K. Rustgi
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
Gastroenterology
Oncology
Online Access:https://doi.org/10.1172/jci.insight.167310

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