MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium

MCU Upregulation Overactivates Mitophagy by Promoting VDAC1 Dimerization and Ubiquitination in the Hepatotoxicity of Cadmium

Abstract Cadmium (Cd) is a high‐risk pathogenic toxin for hepatic diseases. Excessive mitophagy is a hallmark in Cd‐induced hepatotoxicity. However, the underlying mechanism remains obscure. Mitochondrial calcium uniporter (MCU) is a key regulator for mitochondrial and cellular homeostasis. Here, Cd...

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Bibliographic Details
Main Authors: Cong Liu, Hui‐Juan Li, Wei‐Xia Duan, Yu Duan, Qin Yu, Tian Zhang, Ya‐Pei Sun, Yuan‐Yuan Li, Yong‐Sheng Liu, Shang‐Cheng Xu
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
cadmium
hepatotoxicity
mitochondrial calcium uniporter
mitophagy
voltage‐dependent anion‐selective channel protein 1
Online Access:https://doi.org/10.1002/advs.202203869

Internet

https://doi.org/10.1002/advs.202203869

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