HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Summary: The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) is essential to elicit type I interferon cascade response; thus, the activity of cGAS must be strictly regulated to boost the antiviral innate immunity. Here, we report that cGAS is responsible for the DNA-induced ISG15 conjugation sys...

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Bibliographic Details
Main Authors: Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001980

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http://www.sciencedirect.com/science/article/pii/S2211124724001980

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