Combining natural sequence variation with high throughput mutational data to reveal protein interaction sites.
Many protein interactions are conserved among organisms despite changes in the amino acid sequences that comprise their contact sites, a property that has been used to infer the location of these sites from protein homology. In an inter-species complementation experiment, a sequence present in a hom...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-02-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC4335499?pdf=render |