Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-downregulated genes in luminal cells.

Bibliographic Details
Main Authors: Yael Aylon, Noa Furth, Giuseppe Mallel, Gilgi Friedlander, Nishanth Belugali Nataraj, Meng Dong, Ori Hassin, Rawan Zoabi, Benjamin Cohen, Vanessa Drendel, Tomer Meir Salame, Saptaparna Mukherjee, Nofar Harpaz, Randy Johnson, Walter E. Aulitzky, Yosef Yarden, Efrat Shema, Moshe Oren
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34863-9

Internet

https://doi.org/10.1038/s41467-022-34863-9

Similar Items