Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels

Interactions between opposite subunits of HCN channels are relevant for stabilizing the auto-inhibited state of the channel. Like cAMP-binding, K464E-mutation breaks these interactions to favor a channel’s pre-activated state.

Bibliographic Details
Main Authors: Mahesh Kondapuram, Benedikt Frieg, Sezin Yüksel, Tina Schwabe, Christian Sattler, Marco Lelle, Andrea Schweinitz, Ralf Schmauder, Klaus Benndorf, Holger Gohlke, Jana Kusch
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03360-6

Internet

https://doi.org/10.1038/s42003-022-03360-6

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