Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels
Interactions between opposite subunits of HCN channels are relevant for stabilizing the auto-inhibited state of the channel. Like cAMP-binding, K464E-mutation breaks these interactions to favor a channel’s pre-activated state.
Bibliographic Details
| Main Authors: |
Mahesh Kondapuram,
Benedikt Frieg,
Sezin Yüksel,
Tina Schwabe,
Christian Sattler,
Marco Lelle,
Andrea Schweinitz,
Ralf Schmauder,
Klaus Benndorf,
Holger Gohlke,
Jana Kusch |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-05-01
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| Series: | Communications Biology
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| Online Access: | https://doi.org/10.1038/s42003-022-03360-6
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