Genome scale analysis of pathogenic variants targetable for single base editing

Genome scale analysis of pathogenic variants targetable for single base editing

Abstract Background Single nucleotide variants account for approximately 90% of all known pathogenic variants responsible for human diseases. Recently discovered CRISPR/Cas9 base editors can correct individual nucleotides without cutting DNA and inducing double-stranded breaks. We aimed to find all...

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Bibliographic Details
Main Authors: Alexander V. Lavrov, Georgi G. Varenikov, Mikhail Yu Skoblov
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Medical Genomics
Subjects:
Base editor CRISPR/Cas9
ABE
APOBEC
PmCDA1
Pathogenic variants
Hereditary diseases
Online Access:http://link.springer.com/article/10.1186/s12920-020-00735-8

Internet

http://link.springer.com/article/10.1186/s12920-020-00735-8

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