High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial

High-flow nasal therapy versus noninvasive ventilation in COPD patients with mild-to-moderate hypercapnic acute respiratory failure: study protocol for a noninferiority randomized clinical trial

Abstract Background Noninvasive ventilation (NIV) is indicated to treat respiratory acidosis due to exacerbation of chronic obstructive pulmonary disease (COPD). Recent nonrandomized studies also demonstrated some physiological effects of high-flow nasal therapy (HFNT) in COPD patients. We designed...

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Bibliographic Details
Main Authors: Andrea Cortegiani, Federico Longhini, Annalisa Carlucci, Raffaele Scala, Paolo Groff, Andrea Bruni, Eugenio Garofalo, Maria Rita Taliani, Uberto Maccari, Luigi Vetrugno, Enrico Lupia, Giovanni Misseri, Vittoria Comellini, Antonino Giarratano, Stefano Nava, Paolo Navalesi, Cesare Gregoretti
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Trials
Subjects:
High-flow oxygen therapy through nasal cannula
Noninvasive ventilation
Chronic obstructive pulmonary disease
Carbon dioxide
Acute respiratory failure
Intensive care unit
Online Access:http://link.springer.com/article/10.1186/s13063-019-3514-1

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http://link.springer.com/article/10.1186/s13063-019-3514-1

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