A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells

A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells

In this study, we describe a novel kinase inhibitor AX-0085 which can suppress the induction of PD-L1 expression by Interferon-γ (IFN-γ) in lung adenocarcinoma (LUAD) cells. AX-0085 effectively blocks JAK2/STAT1 signaling initiated by IFN-γ treatment and prevents nuclear localization of STAT1. Impor...

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Bibliographic Details
Main Authors: Jusong Kim, Haeyeon Jang, Gyu Jin Lee, Yelim Hur, Juhee Keum, Jung Ki Jo, Si-Eun Yun, Sung Jun Park, Young Jun Park, Myeong Jun Choi, Kye-Seong Kim, Jaesang Kim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cells
Subjects:
AX-0085
PD-L1
immune checkpoint
cancer immunotherapy
lung adenocarcinoma
Online Access:https://www.mdpi.com/2073-4409/11/1/19

Internet

https://www.mdpi.com/2073-4409/11/1/19

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