Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma

Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma

Anterior segment dysgenesis (ASD) encompasses a group of developmental disorders in which a closed angle phenotype in the anterior chamber of the eye can occur and 50% of patients develop glaucoma. Many ASDs are thought to involve an inappropriate patterning and migration of the periocular mesenchym...

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Bibliographic Details
Main Authors: Vanessa B. Martino, Thomas Sabljic, Paula Deschamps, Rebecca M. Green, Monica Akula, Erica Peacock, Alexander Ball, Trevor Williams, Judith A. West-Mays
Format: Article
Language:English
Published: The Company of Biologists 2016-08-01
Series:Disease Models & Mechanisms
Subjects:
Anterior segment dysgenesis
Glaucoma
AP-2β
Online Access:http://dmm.biologists.org/content/9/8/849

Internet

http://dmm.biologists.org/content/9/8/849

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