Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting

Effective Depletion of Pre-existing Anti-AAV Antibodies Requires Broad Immune Targeting

Pre-existing antibodies (Abs) to AAV pose a critical challenge for the translation of gene therapies. No effective approach is available to overcome pre-existing Abs. Given the complexity of Ab production, overcoming pre-existing Abs will require broad immune targeting. We generated a mouse model of...

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Bibliographic Details
Main Authors: Victoria M. Velazquez, Aaron S. Meadows, Ricardo J. Pineda, Marybeth Camboni, Douglas M. McCarty, Haiyan Fu
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
pre-existing antibody
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300074

Internet

http://www.sciencedirect.com/science/article/pii/S2329050117300074

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