A rapid immunization strategy with a live attenuated tetravalent dengue vaccine elicits protective neutralizing antibody responses in non-human primates

A rapid immunization strategy with a live attenuated tetravalent dengue vaccine elicits protective neutralizing antibody responses in non-human primates

Dengue viruses (DENVs) cause approximately 390 million cases of DENV infections annually and over 3 billion people worldwide are at risk of infection. No dengue vaccine is currently available nor is there an antiviral therapy for DENV infections. We have developed a tetravalent live-attenuated DENV...

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Bibliographic Details
Main Authors: Yuping eAmbuel, Ginger eYoung, Joseph eBrewoo, Joanna ePaykel, Kim eWeisgrau, Eva eRakasz, Aurelia eHaller, Michael eRoyals, Claire eHuang, Saverio eCapuono, Dan eStinchcomb, Charalambos ePartidos, Jorge eOsorio
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Immunology
Subjects:
Dengue
Vaccine
non-human primates
neutralizing antibodies
T cell responses
needle-free delivery
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00263/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00263/full

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