Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells

Intrahepatic quantification of HBV antigens in chronic hepatitis B reveals heterogeneity and treatment-mediated reductions in HBV core-positive cells

Background & Aims: Patterns of liver HBV antigen expression have been described but not quantified at single-cell resolution. We applied quantitative techniques to liver biopsies from individuals with chronic hepatitis B and evaluated sampling heterogeneity, effects of disease stage, and nuc...

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Bibliographic Details
Main Authors: Abhishek Aggarwal, Pamela M. Odorizzi, Jens Brodbeck, Nicholas van Buuren, Christina Moon, Silvia Chang, MaryVic Adona, Silpa Suthram, Vithika Suri, Torsten Trowe, Scott Turner, Patrick Marcellin, Maria Buti, Anuj Gaggar, Simon P. Fletcher, Lauri Diehl, Becket Feierbach, Scott Balsitis
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:JHEP Reports
Subjects:
HBV
NUC
HBsAg
HBV core
Biomarkers
HBeAg
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555922002361

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http://www.sciencedirect.com/science/article/pii/S2589555922002361

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