Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

Transforming growth factor-β1 decreases erythropoietin production through repressing hypoxia-inducible factor 2α in erythropoietin-producing cells

Abstract Background Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO is effective to improve anemia, no re...

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Bibliographic Details
Main Authors: Hong-Mou Shih, Szu-Yu Pan, Chih-Jen Wu, Yu-Hsiang Chou, Chun-Yuan Chen, Fan-Chi Chang, Yi-Ting Chen, Wen-Chih Chiang, Hsing-Chen Tsai, Yung-Ming Chen, Shuei-Liong Lin
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Biomedical Science
Subjects:
Erythropoietin
Hypoxia-inducible factor 2α
Pericyte
Transforming growth factor-β1
Online Access:https://doi.org/10.1186/s12929-021-00770-2

Internet

https://doi.org/10.1186/s12929-021-00770-2

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