PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma.

The unfolded protein response (UPR) regulates cell fate following exposure of cells to endoplasmic reticulum stresses. PERK, a UPR protein kinase, regulates protein synthesis and while linked with cell survival, exhibits activities associated with both tumor progression and tumor suppression. For ex...

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Bibliographic Details
Main Authors: Dariusz Pytel, Yan Gao, Katarzyna Mackiewicz, Yuliya V Katlinskaya, Kirk A Staschke, Maria C G Paredes, Akihiro Yoshida, Shuo Qie, Gao Zhang, Olga S Chajewski, Lawrence Wu, Ireneusz Majsterek, Meenhard Herlyn, Serge Y Fuchs, J Alan Diehl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5207760?pdf=render

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http://europepmc.org/articles/PMC5207760?pdf=render

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