Human obstructive (postvasectomy) and nonobstructive azoospermia – Insights from scRNA-Seq and transcriptome analysis

Human obstructive (postvasectomy) and nonobstructive azoospermia – Insights from scRNA-Seq and transcriptome analysis

A substantial number of male infertility is caused by azoospermia. However, the underlying etiology and the molecular basis remain largely unknown. Through single-cell (sc)RNA sequencing, we had analyzed testis biopsy samples from two patients with obstructive azoospermia (OA) and nonobstructive azo...

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Bibliographic Details
Main Authors: Shitao Chen, Geng An, Hanshu Wang, Xiaolong Wu, Ping Ping, Longfei Hu, Yunmei Chen, Jue Fan, C. Yan Cheng, Fei Sun
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-05-01
Series:Genes and Diseases
Subjects:
Androgen signaling
Retinoic acid
Sertoli cell-only syndrome
Single-cell
Spermatogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220301227

Internet

http://www.sciencedirect.com/science/article/pii/S2352304220301227

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