Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors

Design, synthesis, and in silico studies of quinoline-based-benzo[d]imidazole bearing different acetamide derivatives as potent α-glucosidase inhibitors

Abstract In this study, 18 novel quinoline-based-benzo[d]imidazole derivatives were synthesized and screened for their α-glucosidase inhibitory potential. All compounds in the series except 9q showed a significant α-glucosidase inhibition with IC50 values in the range of 3.2 ± 0.3–185.0 ± 0.3 µM, as...

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Bibliographic Details
Main Authors: Milad Noori, Ali Davoodi, Aida Iraji, Navid Dastyafteh, Minoo Khalili, Mehdi Asadi, Maryam Mohammadi Khanaposhtani, Somayeh Mojtabavi, Mehdi Dianatpour, Mohammad Ali Faramarzi, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18455-7

Internet

https://doi.org/10.1038/s41598-022-18455-7

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