Proteomic Analyses Reveal that Sky1 Modulates Apoptosis and Mitophagy in Saccharomyces cerevisiae Cells Exposed to Cisplatin

Proteomic Analyses Reveal that Sky1 Modulates Apoptosis and Mitophagy in Saccharomyces cerevisiae Cells Exposed to Cisplatin

Sky1 is the only member of the SR (Serine–Arginine) protein kinase family in Saccharomyces cerevisiae. When yeast cells are treated with the anti-cancer drug cisplatin, Sky1 kinase activity is necessary to produce the cytotoxic effect. In this study, proteome changes in response to this drug and/or...

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Bibliographic Details
Main Authors: Silvia Rodríguez-Lombardero, M. Esther Rodríguez-Belmonte, M. Isabel González-Siso, Ángel Vizoso-Vázquez, Vanessa Valdiglesias, Blanca Laffón, M. Esperanza Cerdán
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
Bmh1
Bmh2
chemoresistance
yeast
cancer
Online Access:http://www.mdpi.com/1422-0067/15/7/12573

Internet

http://www.mdpi.com/1422-0067/15/7/12573

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