Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress

Inhibition of Microbiota-dependent Trimethylamine N-Oxide Production Ameliorates High Salt Diet-Induced Sympathetic Excitation and Hypertension in Rats by Attenuating Central Neuroinflammation and Oxidative Stress

Excessive dietary salt intake induces neuroinflammation and oxidative stress in the brain, which lead to sympathetic excitation, contributing to hypertension. However, the underlying mechanisms remain elusive. Accumulating evidence reveals that trimethylamine-N-oxide (TMAO), a gut microbiota-derived...

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Bibliographic Details
Main Authors: Gang Liu, Jiayin Cheng, Tianhao Zhang, Yingxin Shao, Xiangxu Chen, Lihong Han, Ru Zhou, Bin Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
high salt diet
trimethylamine N-oxide
neuroinflammation
oxidative stress
hypertension
gut microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.856914/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.856914/full

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