Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target

Ligand activation of liver X receptors (LXRs) has been shown to impact both lipid metabolism and inflammation. One complicating factor in studies utilizing synthetic LXR agonists is the potential for pharmacologic and receptor-independent effects. Here, we describe an LXR gain-of-function system tha...

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Bibliographic Details
Main Authors: Cynthia Hong, Robert Walczak, Helena Dhamko, Michelle N. Bradley, Chaitra Marathe, Rima Boyadjian, Jon V. Salazar, Peter Tontonoz
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Journal of Lipid Research
Subjects:
ADP-ribosylation factor-like 7
liver X receptor
nuclear receptor
macrophage
inflammation
lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520409332

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http://www.sciencedirect.com/science/article/pii/S0022227520409332

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