Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

Novel protocol for multiple-dose oral administration of the L-type Ca2+ channel blocker isradipine in mice: A dose-finding pharmacokinetic study

ABSTRACTStudies in genetically modified animals and human genetics have recently provided new insight into the role of voltage-gated L-type Ca2+ channels in human disease. Therefore, the inhibition of L-type Ca2+ channels in vivo in wildtype and mutant mice by potent dihydropyridine (DHP) Ca2+ chann...

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Bibliographic Details
Main Authors: Tamara Theiner, Nadine J. Ortner, Herbert Oberacher, Gospava Stojanovic, Petronel Tuluc, Jörg Striessnig
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Channels
Subjects:
Calcium channel blockers
dihydropyridines
pharmacokinetics
drug administration
voltage-gated calcium channels
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2024.2335469

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2024.2335469

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