Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

When complexed with antigenic peptides, human leukocyte antigen (HLA) class I (HLA-I) molecules initiate CD8+ T cell responses via interaction with the T cell receptor (TCR) and co-receptor CD8. Peptides are generally critical for the stable cell surface expression of HLA-I molecules. However, for H...

Full description

Bibliographic Details
Main Authors: Jie Geng, John D Altman, Sujatha Krishnakumar, Malini Raghavan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
HLA class I
CD8
empty HLA
immunological synapse
HLA-B
HLA-B*35:01
Online Access:https://elifesciences.org/articles/36341

Similar Items

Similar Items