1,3-Substituted Imidazolidine-2,4,5-triones: Synthesis and Inhibition of Cholinergic Enzymes

1,3-Substituted Imidazolidine-2,4,5-triones: Synthesis and Inhibition of Cholinergic Enzymes

A series of novel and highly active acetylcholinesterase and butyrylcholinesterase inhibitors derived from substituted benzothiazoles containing an imidazolidine-2,4,5-trione moiety were synthesized and characterized. The molecular structure of 1-(2,6-diisopropyl-phenyl)-3-[(1R)-1-(6-fluoro-1,3-benz...

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Bibliographic Details
Main Authors: Josef Jampilek, Ales Imramovsky, Zdenka Padelkova, Sarka Stepankova, Vladimir Pejchal
Format: Article
Language:English
Published: MDPI AG 2011-09-01
Series:Molecules
Subjects:
1-(aryl)-3-[(R)-1-(6-fluorobenzo[d]thiazol-2-yl)ethyl]imidazolidine-2,4,5-triones
X-ray diffraction
lipophilicity
in vitro acetylcholinesterase inhibition
in vitro butyrylcholinesterase inhibition
structure-activity relationships
Online Access:http://www.mdpi.com/1420-3049/16/9/7565/

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http://www.mdpi.com/1420-3049/16/9/7565/

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