Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Abstract CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications. Coincidently, CRISPR/Cas gene-editing technology is entering next-generation CAR T cell product manufacturing with the promise of more precise and mo...

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Bibliographic Details
Main Authors: Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04978-w

Internet

https://doi.org/10.1038/s42003-023-04978-w

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