Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats

Effects of 17-AAG on the RIP1/RIP3/MLKL pathway during the development of heart failure following myocardial infarction in rats

In a previous study, we suggested that the Hsp90 inhibitor 17-AAG prevents cardiac dysfunction in the failing heart following myocardial infarction in rats. Although it is assumed that the RIP1/RIP3/MLKL necroptotic pathway, which comprises client proteins for Hsp90, is involved; however, the relati...

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Bibliographic Details
Main Authors: Tetsuro Marunouchi, Takumi Ito, Sumika Onda, Lina Kyo, Kirara Takahashi, Manami Uchida, Emi Yano, Kouichi Tanonaka
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Pharmacological Sciences
Subjects:
Heart failure
Myocardial infarction
Hsp90 inhibitor
MLKL
RIP
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000657

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http://www.sciencedirect.com/science/article/pii/S1347861321000657

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