Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease

Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced disease

Abstract Background Graves’ disease (GD) is an autoimmune condition in which autoantibodies to the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have Graves’ orbitopathy (GO), an intractable disease in which expansion of the orbital contents causes diplopia, propto...

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Main Authors: Sajad Moshkelgosha, Hedda Luise Verhasselt, Giulia Masetti, Danila Covelli, Filippo Biscarini, Mareike Horstmann, Anke Daser, Astrid M. Westendorf, Christoph Jesenek, Svenja Philipp, Salvador Diaz-Cano, J. Paul Banga, Daryn Michael, Sue Plummer, Julian R. Marchesi, Anja Eckstein, Marian Ludgate, Utta Berchner-Pfannschmidt, and the INDIGO consortium
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Microbiome
Subjects:
Graves’ disease
Graves’ orbitopathy
Murine model
Gut microbiota
Microbiome modulation
Vancomycin
Online Access:https://doi.org/10.1186/s40168-020-00952-4

Internet

https://doi.org/10.1186/s40168-020-00952-4

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