New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation

New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation

New sets of ibuprofen and indomethacin conjugates comprising triazolyl heterocycle were synthesized via click chemistry, adopting an optimized protocol through the molecular hybridization approach affording the targeted agents in good yields. The new non-steroidal anti-inflammatory drug (NSAID) conj...

Full description

Bibliographic Details
Main Authors: Riham M. Bokhtia, Siva S. Panda, Adel S. Girgis, Nermin Samir, Mona F. Said, Anwar Abdelnaser, Soad Nasr, Mohamed S. Bekheit, Abdelhameed S. Dawood, Horrick Sharma, Margaret Wade, Swapnil K. Sharma, Amany M. Ghanim
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
ibuprofen
indomethacin
anti-inflammatory
analgesic
COX
molecular modeling
Online Access:https://www.mdpi.com/1420-3049/28/4/1945

Internet

https://www.mdpi.com/1420-3049/28/4/1945

Similar Items